Using a locked program is the same as using the program when it is unlocked - simply open its program file or a link to it. Before the program is run, EXEsafe will determine if you are able to run the program, and ask for passwords if required.
If a program has been moved, it will update its new position in EXEsafe. If, for some reason it becomes unlocked or invalid, it will also be removed from EXEsafe.